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The is a now extinct clan, known for their savage battle tactics and archaic values, and as descendants of Kaguya Ōtsutsuki, a select few have inherited a derivative of her original ability to manipulate one's bone structures.
The Kaguya clan's destruction.
The Kaguya Clan were descendants of Kaguya Ōtsutsuki, and selective few, namely Kimimaro, possessed the kekkei genkai Shikotsumyaku from Kaguya's original bone-manipulating ability. This ability was so powerful that even the war-loving Kaguya Clan feared it.
The clan was noted for being very savage and battle-hungry, having no tactics when entering battle that they initiated simply to show off their ferocity. It was due to this failed attempt to prove themselves that the entire clan was killed off when attacking Kirigakure; even when surrounded and completely outmatched, they refused to back down, preferring to fight to the death simply to entertain their own bloodlust to the last.
Kimimaro was the only one of the clan to survive, as he did not share the same urge for barbaric slaughter as the others, and after being adopted by Orochimaru, he would live as the last of the Kaguya Clan for several years, but eventually died of a terminal illness.
The clan shares their name with the progenitor of their kekkei genkai: Kaguya. The marking on their foreheads also seem to be replications of her own shortly cut eyebrows and the zigzag cranial pattern right in between their heads which served as visible sign of her nobility.
In an interview with Naruto creator Masashi Kishimoto, he mentioned that the two markings on the Kaguya Clan members' foreheads are based off of the marks on aristocrats during the Heian period.
The clan's hairstyle seems to be inspired by Yayoi period styles.